Sunday, May 17, 2020

Skin Stem Cells - Free Essay Example

Sample details Pages: 2 Words: 673 Downloads: 3 Date added: 2019/06/13 Category Biology Essay Level High school Tags: Stem Cell Essay Did you like this example? Adult stem cells are the undifferentiated cells that are involved in the maintenance, renewal, and repair of various tissues and organs. These stem cells are found in particular niche in a tissue or an organ where they remain undifferentiated and are activated to undergo division and differentiation to maintain the tissue or when activated by disease or disruption. Skin undergoes constant renewal and it is crucial to study the dynamic pathways and key regulators involved at the transcriptional level in proliferation and differentiation of adult stem cells. Don’t waste time! Our writers will create an original "Skin Stem Cells" essay for you Create order In Skin, there are different adult stem cells are located in various locations and can be isolated based on their unique cell surface marker expression. Like epithelium, hair follicles also undergo constant regeneration and have a niche for adult stem cells in the bulge region. Bulge stem cells have shown to regenerate various cell types of the epidermis and when grown in vitro to have shown high proliferation and large colony formation in vitro [1]. The keratinocytes isolated also have shown to be accumulating mutations to form malignant cancers. Skin cancer is one of the most prevalent cancers in United States with around 5 million people being diagnosed and an average of 8 billion dollars is spent on the treatment for skin cancer annually. The statistics on the financial burden on skin cancer and the increasing cases of melanoma and non-melanoma cases detected each year shows the need for research and understanding the underlying mechanisms to prevent skin cancer [2]. As these adult stem cells have such unique characteristics, it is important to know about the key regulators involved in the cell proliferation, cell differentiation, immunity and pathways that lead the cells to become cancerous. Apart from the above tissue specific properties there is also a huge interest in trying to understand universal adult stem cells property and their involvement in cancer. With advances in high throughput sequencing, we are now able to study differential gene expression across various cells and tissues. Deeper sequencing techniques have enabled to sequence the major chunk of the genome which is non-coding transcriptome. RNA-sequencing has made it easy to compare gene expression profiles across samples and in-between two cell types from the same tissue and gives an insight into gene expression, tissue pattern or cell specificity of both protein coding genes and non-coding genes. Having this data will help us understand the key regulators which participate in s tem cell proliferation, differentiation and in our study, genes involved in high colony formation. By isolating specific stem cells from mouse model, it will help us design an experimental model which will allow us to compare the data with publicly available data bases to understand the roles and functions of key regulators involved. Among the non-coding RNAs, long non-coding (lncRNA) RNAs have shown to be involved in regulation, stem cell differentiation and tumor promotion. With increasing evidences of lncRNAs involvement in gene regulation, we decided to look into them and how they are differentially expressed and affect the nearby protein coding genes in our cells of interest from the C57BL6 mouse. LncRNAs are more than 200 bp in length and are involved in gene regulation at transcriptional and post-translational level. They bind with proteins, transcription factors and by binding with other ncRNA alter gene expression. It is also known that lncRNA are tissue specific and are differentially expressed in higher numbers compared with protein-coding genes [3]. In databases like Gencode, they have reported a total of 28468 lncRNA genes in human and 17855 lncRNA genes in mouse [4]. Most of the functions of lncRNAs are still unknown. Identifying differentially expressed genes will be the first step to look into imp ortant genes and pathways that regulate the stem cell characteristics of hair bulge cells compared to the nearby non-stem cell population. To understand better how Long non-coding and mRNA work in the skin we are including parameters like the location of lncRNA and gene expression pattern of selected lncRNA-mRNA across different cancer types to know the function and possible regulatory mechanism of lncRNA on nearby protein-coding genes. Keratinocyte stem cells and cancer

Wednesday, May 6, 2020

Advertising and Society - 2565 Words

Advertising and Society Introduction: Advertising is said to be like glue that holds cultures together. It allows us to share a common experience incorporated by brands, images, logos, and even silly jingles. We define who we are by what we buy and wear because we know that others judge us by what we buy and wear. And advertising influences those judgments. Today because of advertisements conditioning and trendsetting, judgments are made on what clothes people wear, what shampoo and kitchen cleaner they use, not on whom we really are. This leads to a certain degree of social discrimination and emotional insecurity especially in younger population. In advertising, socio-cultural dimensions came in 1920’s. Agencies and publicists no†¦show more content†¦Then he discussed about the role of advertising in developing ideas about the imaginary world. To elaborate his point the author added the analysis by Cronic in 2000.who argued about the imagination of audience and their relationship and said that they cannot be discovered. Moreover he discussed the post modern and cultural critiques of advertising which were based on the modes of consumption. Then he put studies by Matterlart in 1991 and Kenway and Bullen in 2001 which emphasized on the domination of public space and consumption of advertising where as Jameson in 1991 and Baudrilland in 1988 argued about post-modern ways of criticizing advertising. They said that there is a lack of distinction between the real and imaginary world. The main crux of their studies was that advertising creates hyper reality. In order to relate advertising with other different phenomenon’s he discussed about discourse, ideology, myths and representations. According to author there is an interrelationship between discourses, ideologies myths and representations. For discourses he took the example of car advertisement that how they used technology as a discourse in relation to different environments Moreover he added myths as false ideas about consciousness of ideology as in advertisements of beauty products. According to him advertising not only affects our consciousness butShow MoreRelatedAdvertising And Its Effects On Society844 Words   |  4 Pageslogo, and flyers left on windshields as a form of advertising (2011, p.130). According to Medoff and Kaye, advertising serves an educational, social and economic purpose (2011, p.137). Although advertising appears beneficial in many features, it too has its drawbacks and can be similarly unfavorable. Advertising will perhaps become increasingly ubiqui tous, increasingly influential, and increasingly controversial (Advertising, 2011, p.152). Advertising is highly criticized, not so much for its very natureRead MoreAdvertising And Its Effects On Society1167 Words   |  5 PagesCome To Advertising has found ways to be subtle about how they go about demeaning and dehumanizing different genders, races, ages, ethnicities, cultures, and sexual orientations. Society would like to believe that advertising has improved from the days of showing women’s place in the kitchen and only having light skinned models but now advertising companies have just become sneakier and wittier about the way they portray people and the worst part is that society encourages it. Society, as a wholeRead MoreEffect Of Advertising On Society Essay1728 Words   |  7 PagesTalking about advertising, on the one hand, it is good for its functions, displays, etc.; on the other hand, sometimes it is too good to be true, the way they bring the messages to the consumers which state â€Å"the number one †¦Ã¢â‚¬ . What truly are the miscommunications and how do the viewers react to different types of stimulation among those, are there negative or positive results? This review of literature scope was led by the following question: When it comes to communication and advertising are there positiveRead MoreAdvertising And Its Effect On Society1442 Words   |  6 Pagesproduct. Although sometimes advertising can be quite annoying, it can also help in persuading you to buy a product or service. You may be looking for a specific product for a specific purpose or maybe you have heard of a product simply through its exemplary advertising. There are different viewpoints to advertising and many different ways that it appeals and relates to us as individuals and as a society. Today, in order for the advertisements to stay true to their advertising, there has been a set ofRead MoreDeception in Advertising to the Society865 Words   |  3 Pagesthe end. Society considers deception as a relational transgression, which normally leads to betrayal and mistrust among individuals. Deception can take many forms that may include propaganda, dissimulation, distraction, concealment, camou flage and even self-deception (Carson, 2010). Advertising and Deception The most common form of deception is the use of misleading or false statements in commercial transactions. This is referred to as deceptive or false advertising. False advertising is any promotionRead MoreAdvertising And Its Impact On Society1178 Words   |  5 Pagescomes to advertising these differences are not put aside, especially in terms of gender and race. According to Schroeder Borgerson (1998), advertising is quite significant when influencing, building and illustrating consumers vision of the good life, which includes sexual attraction. Domzal Kernan (1993), added that, advertising images represent an essential part of the experienced visual world. Reality and advertising are notRead MoreAdvertising Impact on Society 1190 Words   |  5 PagesAdvertising’s impact on Society Marshall McLuhan, a Canadian philosopher of communication theory said, â€Å"Advertising is the greatest art form of the 20th century.† Like many works of art, advertising is constantly pushing the limits of what is appropriate. It is hard to escape the constant bombardment of advertisements; they are all around us and they have an impact on our cultural values as a society. Industries take full advantage of this constant exposure in order to sell their products, so asRead MoreAdvertising in our Society 555 Words   |  2 PagesAdvertising is the process of communication where a person or groups of people are persuaded to take some form of action, usually to make a purchase or participate in a particular behavior. Advertisements are used in hopes to increase the number of people that use their products or services. All product advertisements try to make people buy their products, so they manipulate facts about the product to make it more appealing to the consumer. Advertiseme nts have such a high level of advertising aroundRead MoreThe Effect Of Advertising On Society1911 Words   |  8 Pagespromotions as they see it as an essential tool in an increasingly capitalistic free market to fuel economic growth. Unfortunately, the surge of unchecked advertising has lead to some adverse effects on societies whether they be moral or ethical in nature. The SAFRA gym advertisement, is an impeccable example of the adverse effects of advertising in today’s society. The advertisement depicts a lean woman who is wearing purple tank top and tight black leggings working out uncomfortably, as two men watched herRead MoreThe Effects Of Advertising On The Society936 Words   |  4 Pagesmarket; conversely competition can go too far or form into something entirely different. In addition, some companies will do anything to boost sales even if that means sacrificing common etiquette or logic to the masses and against their rivals. Advertising is always evolving and a dapting, and for now companies and their advertisers through their advertisements are appearing more cynical and critical by the day. Competition has been a motivating force since man was created. It is a driving pressure

Description of a Religious Festival free essay sample

Write an essay describing a religious festival you celebrated, mentioning what you saw and did in the festival Religion is a â€Å"collective conscience†, a shared outlook created by ceremonies. Most common religion in India is Hinduism. Hindus celebrate thousands of events every year and each in a similar manner, including chanting prayers to the gods and making sweets. Ram Navmi is also one of the event celebrated Hindus. This occasion has great momentousness therefore it’s a nationwide holiday. It is celebrated two days after the seven navratras. Navratras are the days of ‘pooja’ in which Goddess Durga is worshipped by the people for bringing peace and prosperity in their life. People especially ladies keep fast for the first eight days and open on the ninth day. Goddess Durga have nine different incarnations, worshipped one each day. Havans are done, which is also believed by the people that it’s smoke purify the homes. We will write a custom essay sample on Description of a Religious Festival or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page On the ninth day a bigger ‘havan’ is done and then ladies in the family prepare meals for seven young girls and one boy. These girls are treated with respect as they are considered the different forms of Goddess Durga. They are also given offerings in the form of cash. We also celebrate Ram Navmi and so my mother kept a fast for two days. We could not do havan on the first eight days due to lack of space but on the ninth day we had a ‘pandal’ built, made up of tent cloth which was all red in colour which was to give the event its effect supported by thin logs. A pandit was called to conduct the rights and rituals and my mother prepared food for the girls. The eighth day was hectic for me bit I enjoyed it . my sister and I prepared the invitations cards for the children. They had a silver colored fringe with text in golden and a picture of Lord Ganesha with red background. I went to each one’s house to invite them. I also went to buy eight gifts and keeping in mind their ages I found all the appropriate gifts. Then came the ninth day, I was woke up from my sleep by the ‘shank’ sound. I took my bath and got ready for the function. The ‘havan’ started and gradually the girls also came and there was deluge of tasks poured upon me. I had to bring the bucket full of water to wash the ‘kanyas’ feet. Then I went to help the pandit with ‘ghee’,’yoghurt’, etc.